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Article

Perifosine‐induced inhibition of akt attenuates brain‐derived neurotrophic factor/TrkB‐induced chemoresistance in neuroblastoma in vivo

16 May 2011

Abstract excerpt

BACKGROUND: Neuroblastoma (NB) tumors expressing high levels of brain-derived neurotrophic factor (BDNF) and its receptor TrkB or activated Akt are associated with decreased event-free or overall survival in patients with NB. In the current study, the effect of perifosine, an Akt inhibitor, on the chemosensitivity of TrkB-expressing NB cells or tumors was evaluated. METHODS: A tetracycline-regulated...

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PMID: 21590687
DOI: 10.1002/cncr.26133

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Perifosine‐induced inhibition of akt attenuates brain‐derived neurotrophic factor/TrkB‐induced chemoresistance in neuroblastoma in vivoPMID 21590687Read ↗

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