Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.

Journal of the National Cancer Institute - 2 Jun 2010

Li Zhijie, Tan Fei, Liewehr David J, Steinberg Seth M, Thiele Carol J

Abstract excerpt

BACKGROUND: Activated AKT is a marker of decreased event-free or overall survival in neuroblastoma (NB) patients. The aim of this study was to investigate the effect of perifosine, a nontoxic AKT inhibitor, as a single agent on NB cell growth in vitro and in vivo. METHODS: Four human NB cell lines (AS, NGP, BE2, and KCNR) were treated with increasing concentrations of perifosine, and a quantitative analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Caspase 7
Share to Growth Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Neuroblastoma

Share to NIH 3T3 Cells

Share to Phosphorylcholine

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 20463309
DOI: 10.1093/jnci/djq125
PMCID: PMC2879416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.PMID 20463309Read ↗

Perifosine‐induced inhibition of akt attenuates brain‐derived neurotrophic factor/TrkB‐induced chemoresistance in neuroblastoma in vivoSemantic proximity Read ↗

Perifosine as a potential novel anti-telomerase therapySemantic proximity Read ↗

Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell lineSemantic proximity Read ↗

Genetic and Pharmacologic Identification of Akt as a Mediator of Brain-Derived Neurotrophic Factor/TrkB Rescue of Neuroblastoma Cells from Chemotherapy-Induced Cell DeathSemantic proximity Read ↗

Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.Semantic proximity Read ↗

Perifosine selectively induces cell cycle block and modulates retinoblastoma and E2F1 protein levels in p53 mutated leukemic cell lines.Semantic proximity Read ↗

Cell Survival Signaling in NeuroblastomaSemantic proximity Read ↗

Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.