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Article

Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.

European journal of pharmacology - 5 May 2021

Morii Yusuke, Tsubaki Masanobu, Takeda Tomoya, Otubo Rie, Seki Shiori, Yamatomo Yuta, Imano Motohiro, Satou Takao, Shimomura Kazunori, Nishida Shozo

Abstract excerpt

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation in colon cancer contributes to the poor prognosis of the disease and chemoresistance of tumors. New therapies are needed; however, the lack of knowledge of the mechanism of chemoresistance has hindered progress. In this study, we investigated the mechanism of the reduced sensitivity of colon cancer cells to 5-fluorouracil...

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Identifiers

PMID: 33662352
DOI: 10.1016/j.ejphar.2021.173957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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