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Article

Deletion of lysine 84 to lysine 89 enhances the cytotoxicity and the receptor binding affinity of human lymphotoxin.

The Journal of biological chemistry - 5 May 1990

Wakabayashi T, Asada M, Nagasu T, Iijima A, Hasegawa Y, Shikata Y, Kitoh K

Abstract excerpt

Human lymphotoxin (hLT) and its mutant genes have been constructed by in vitro mutagenesis and expressed in Escherichia coli. A deletion of Lys84 to Lys89 in hLT remarkably enhanced both the cytotoxicity against human WiDr cells (colon adenocarcinoma cell line) and the prostaglandin E2-inducing activity toward human synovial cells by approximately 1000- and 50-fold, respectively. The enhanced biological potency...

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PMID: 2159004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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