Deletion of lysine 84 to lysine 89 enhances the cytotoxicity and the receptor binding affinity of human lymphotoxin.

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Article

Deletion of lysine 84 to lysine 89 enhances the cytotoxicity and the receptor binding affinity of human lymphotoxin.

The Journal of biological chemistry - 5 May 1990

Wakabayashi T, Asada M, Nagasu T, Iijima A, Hasegawa Y, Shikata Y, Kitoh K

Abstract excerpt

Human lymphotoxin (hLT) and its mutant genes have been constructed by in vitro mutagenesis and expressed in Escherichia coli. A deletion of Lys84 to Lys89 in hLT remarkably enhanced both the cytotoxicity against human WiDr cells (colon adenocarcinoma cell line) and the prostaglandin E2-inducing a...

Topics

Amino Acid Sequence
Animals
Cell Line
Cell Survival
Chromosome Deletion
Circular Dichroism
Cloning, Molecular
Escherichia coli
Genes
Genetic Vectors
Humans
Kinetics
Lymphotoxin-alpha
Lysine
Mice
Molecular Sequence Data
Mutation
Protein Conformation

Source

Open in PubMed

Identifiers

PMID: 2159004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2159004-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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