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Article

The intramolecular agonist is obligate for activation of glycoprotein hormone receptors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2020

Schulze Annelie, Kleinau Gunnar, Neumann Susanne, Scheerer Patrick, Schöneberg Torsten, Brüser Antje

Abstract excerpt

In contrast to most rhodopsin-like G protein-coupled receptors, the glycoprotein hormone receptors (GPHR) have a large extracellular N-terminus for hormone binding. The hormones do not directly activate the transmembrane domain but mediate their action via a, thus, far only partially known Tethered Agonistic LIgand (TALI). The existence of such an intramolecular agonist was initially indicated by site-directed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32648604
DOI: 10.1096/fj.202000100R

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