Article
Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group.
BMC cancer - 17 May 2011
Yoon Harry H, Catalano Paul J, Murphy Kathleen M, Skaar Todd C, Philips Santosh, Powell Mark, Montgomery Elizabeth A, Hafez Michael J, Offer Steven M, Liu Geoffrey, Meltzer Stephen J, Wu Xifeng, Forastiere Arlene A, Benson Al B, Kleinberg Lawrence R, Gibson Michael K
Abstract excerpt
BACKGROUND: Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. In addition, whether germline DNA may serve as a surrogate for tumor genotype at this locus is...
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