Article
Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis.
PloS one - 1 Jan 2012
Zhu Mei-Ling, Wang Mengyun, Cao Zhi-Gang, He Jing, Shi Ting-Yan, Xia Kai-Qin, Qiu Li-Xin, Wei Qing-Yi
Abstract excerpt
BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessive syndrome, and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity phenotype and cancer risk. However, a series of...
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