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Article

Inhibition of cyclooxygenase-2 modulates phenotypic switching of vascular smooth muscle cells during increased aortic blood flow.

Heart and vessels - 1 May 2012

Roan Jun-Neng, Tsai Yu-Chuan, Chen I-Wen, Chang Shih-Wei, Huang Chien-Chi, Lam Chen-Fuh

Abstract excerpt

This study investigates the interactions between cyclooxygenase (COX-2) and vascular smooth muscle cell (VSMC) phenotypic switching, the two important coupling mechanisms of the vasculature on arterial remodeling in response to high laminal shear stress. High aortic blood flow was induced by creating a fistula in the abdominal aorta and the adjacent IVC of anesthetized rats. Celecoxib, a selective COX-2 inhibitor...

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Identifiers

PMID: 21584750
DOI: 10.1007/s00380-011-0148-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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