Article
Alteration in the receptor binding specificity of human growth hormone by genomic exon exchange.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1990
Ray J, Okamura H, Kelly P A, Liebhaber S A, Cooke N E
Abstract excerpt
The biological activities of the GH-PRL family of hormones are mediated by selective binding to two classes of cell membrane receptors, somatogen and lactogen. Primate GH such as human GH (hGH) are unusual in that they bind to both classes of receptors. Replacement of exons 3 or 4 of the hGH gene by the corresponding exons of the rat PRL or rat GH genes results in the synthesis of chimeric proteins which retain...
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