Article
Human growth hormone-variant is a biologically active somatogen and lactogen.
Endocrinology - 1 Mar 1991
MacLeod J N, Worsley I, Ray J, Friesen H G, Liebhaber S A, Cooke N E
Abstract excerpt
The human GH-variant (hGH-V) gene, a member of the GH-PRL gene family, is expressed by the placenta during the second and third trimesters of gestation. The secreted hGH-V protein differs from pituitary GH (hGH-N) by only 13 amino acids. We have previously demonstrated that hGH-V can bind to both somatogen and lactogen cell surface receptors in vitro, but that the ratio of its somatogen to lactogen...
Topics
- Animals
- Biological Assay
- Body Weight
- Cell Division
- Cell Line, Transformed
- Genetic Variation
- Growth Hormone
- Humans
- Hypophysectomy
- Lactation
- Lymphoma
- Male