Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.

doi:10.1128/JVI.65.2.700-710.1991

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Article

Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.

Journal of virology - 1 Feb 1991

Johnson P A, Best M G, Friedmann T, Parris D S

Abstract excerpt

We isolated a cell line, designated V9, stably transformed with the herpes simplex virus type 1 (HSV-1) UL42 gene, which is one of seven genes required in trans for the replication of plasmids containing an HSV origin of replication (C. A. Wu, N. J. Nelson, D. J. McGeoch, and M. D. Challberg, J. Virol. 62:435-443, 1988). V9 cells inducibly expressed the product of the UL42 gene, the 65-kDa DNA-binding protein...

Topics

Animals
Base Sequence
Cell Line
Cell Transformation, Viral
Chromosome Deletion
DNA
DNA Replication
DNA, Viral
Genes, Viral
Genetic Complementation Test
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Oligonucleotide Probes

Phenotype

Plasmids

Restriction Mapping

Simplexvirus

Vero Cells

Source

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Identifiers

PMID: 1846193
DOI: 10.1128/JVI.65.2.700-710.1991
PMCID: PMC239809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846193-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.PMID 1846193Read ↗

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