Article
Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.
Journal of acquired immune deficiency syndromes - 1 Jan 1990
Morrey J D, Warren R P, Okleberry K M, Burger R A, Johnston M I, Sidwell R W
Abstract excerpt
Infection with the Friend virus complex (FV) in (B10.A x A/WySn)F1 mice containing the Rfv-3r/s genotype results in several disease manifestations analogous to those seen in patients with acquired immune deficiency syndrome, predominantly high levels of specific antibody and low levels of infectious virus with eventual retroviral disease-induced death of the host. Other immunologic manifestations of FV infection...
Topics
- Animals
- Antibodies, Viral
- Disease Models, Animal
- Friend murine leukemia virus
- Genotype
- HIV Infections
- Killer Cells, Natural
- Leukocyte Count
- Macrophages
- Male
- Mice