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Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: dose-efficacy studies upon oral administration

2018-08-24

Abstract excerpt

<h4>Background</h4> Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), is a viral hemorrhagic fever with a high case fatality rate. Favipiravir was reported to be effective in the treatment of SFTSV infection in vivo in type I interferon receptor knockout (IFNAR -/- ) mice at treatment dosages of both 60 mg/kg/day and 300 mg/kg/day for a duration of 5 days. <h4>Methods</h4> In t...

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Literature Corpus work
f256c0f4-0f19-53f7-98e0-ae98dbbd658d
DOI
10.1101/399899
Open publication

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