Article
Behavioral and in vivo electrophysiological evidence for presymptomatic alteration of prefrontostriatal processing in the transgenic rat model for huntington disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2011
Höhn Sophie, Dallérac Glenn, Faure Alexis, Urbach Yvonne K, Nguyen Huu Phuc, Riess Olaf, von Hörsten Stephan, Le Blanc Pascale, Desvignes Nathalie, El Massioui Nicole, Brown Bruce L, Doyère Valerie
Abstract excerpt
Cognitive decline precedes motor symptoms in Huntington disease (HD). A transgenic rat model for HD carrying only 51 CAG repeats recapitulates the late-onset HD phenotype. Here, we assessed prefrontostriatal function in this model through both behavioral and electrophysiological assays. Behavioral examination consisted in a temporal bisection task within a supra-second range (2 vs.8 s), which is thought to...
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