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Article

srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity.

Molecular biology of the cell - 1 Nov 2013

Yamazaki Daisuke, Itoh Toshiki, Miki Hiroaki, Takenawa Tadaomi

Abstract excerpt

The distinct levels of Rac activity differentially regulate the pattern of intrinsic cell migration. However, it remains unknown how Rac activity is modulated and how the level of Rac activity controls cell migratory behavior. Here we show that Slit-Robo GAP 1 (srGAP1) is a modulator of Rac activity in locomotive cells. srGAP1 possesses a GAP activity specific to Rac1 and is recruited to lamellipodia in a...

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Identifiers

PMID: 24006490
DOI: 10.1091/mbc.E13-04-0178
PMCID: PMC3814155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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