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Article

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

Genes & development - 1 Jun 2011

Dai Ning, Rapley Joseph, Angel Matthew, Yanik M Fatih, Blower Michael D, Avruch Joseph

Abstract excerpt

Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an oncofetal RNA-binding protein. IMP2 is doubly phosphorylated in a rapamycin-inhibitable, amino acid-dependent manner in...

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Identifiers

PMID: 21576258
DOI: 10.1101/gad.2042311
PMCID: PMC3110954

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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