Article
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Human molecular genetics - 1 Mar 2015
Painter Jodie N, O'Mara Tracy A, Batra Jyotsna, Cheng Timothy, Lose Felicity A, Dennis Joe, Michailidou Kyriaki, Tyrer Jonathan P, Ahmed Shahana, Ferguson Kaltin, Healey Catherine S, Kaufmann Susanne, Hillman Kristine M, Walpole Carina, Moya Leire, Pollock Pamela, Jones Angela, Howarth Kimberley, Martin Lynn, Gorman Maggie, Hodgson Shirley, De Polanco Ma Magdalena Echeverry, Sans Monica, Carracedo Angel, Castellvi-Bel Sergi, Rojas-Martinez Augusto, Santos Erika, Teixeira Manuel R, Carvajal-Carmona Luis, Shu Xiao-Ou, Long Jirong, Zheng Wei, Xiang Yong-Bing, Montgomery Grant W, Webb Penelope M, Scott Rodney J, McEvoy Mark, Attia John, Holliday Elizabeth, Martin Nicholas G, Nyholt Dale R, Henders Anjali K, Fasching Peter A, Hein Alexander, Beckmann Matthias W, Renner Stefan P, Dörk Thilo, Hillemanns Peter, Dürst Matthias, Runnebaum Ingo, Lambrechts Diether, Coenegrachts Lieve, Schrauwen Stefanie, Amant Frederic, Winterhoff Boris, Dowdy Sean C, Goode Ellen L, Teoman Attila, Salvesen Helga B, Trovik Jone, Njolstad Tormund S, Werner Henrica M J, Ashton Katie, Proietto Tony, Otton Geoffrey, Tzortzatos Gerasimos, Mints Miriam, Tham Emma, Hall Per, Czene Kamila, Liu Jianjun, Li Jingmei, Hopper John L, Southey Melissa C, Ekici Arif B, Ruebner Matthias, Johnson Nicola, Peto Julian, Burwinkel Barbara, Marme Frederik, Brenner Hermann, Dieffenbach Aida K, Meindl Alfons, Brauch Hiltrud, Lindblom Annika, Depreeuw Jeroen, Moisse Matthieu, Chang-Claude Jenny, Rudolph Anja, Couch Fergus J, Olson Janet E, Giles Graham G, Bruinsma Fiona, Cunningham Julie M, Fridley Brooke L, Børresen-Dale Anne-Lise, Kristensen Vessela N, Cox Angela, Swerdlow Anthony J, Orr Nicholas, Bolla Manjeet K, Wang Qin, Weber Rachel Palmieri, Chen Zhihua, Shah Mitul, French Juliet D, Pharoah Paul D P, Dunning Alison M, Tomlinson Ian, Easton Douglas F, Edwards Stacey L, Thompson Deborah J, Spurdle Amanda B
Abstract excerpt
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive...