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Article

Structural and functional impact of cancer-related missense somatic mutations.

Journal of molecular biology - 21 Oct 2011

Shi Zhen, Moult John

Abstract excerpt

A number of large-scale cancer somatic genome sequencing projects are now identifying genetic alterations in cancers. Evaluation of the effects of these mutations is essential for understanding their contribution to tumorigenesis. We have used SNPs3D, a software suite originally developed for analyzing nonsynonymous germ-line variants, to identify single-base mutations with a high impact on protein structure and...

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Identifiers

PMID: 21763698
DOI: 10.1016/j.jmb.2011.06.046
PMCID: PMC4177034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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