Identifying human disease genes through cross-species gene mapping of evolutionary conserved processes.

doi:10.1371/journal.pone.0018612

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Article

Identifying human disease genes through cross-species gene mapping of evolutionary conserved processes.

PloS one - 4 May 2011

Poot Martin, Badea Alexandra, Williams Robert W, Kas Martien J

Abstract excerpt

BACKGROUND: Understanding complex networks that modulate development in humans is hampered by genetic and phenotypic heterogeneity within and between populations. Here we present a method that exploits natural variation in highly diverse mouse genetic reference panels in which genetic and environmental factors can be tightly controlled. The aim of our study is to test a cross-species genetic mapping strategy,...

Topics

Animals
Chromosome Mapping
Corpus Callosum
DNA Copy Number Variations
Genotype
Humans
Magnetic Resonance Imaging
Mice
Quantitative Trait Loci

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PMID: 21572526
DOI: 10.1371/journal.pone.0018612
PMCID: PMC3087714

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