Article
TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice.
Nature methods - 1 Feb 2026
Huang Shangzheng, Zhang Tongyu, Dong Changsheng, Shi Yingchao, Peng Yingjie, Liu Xiya, Li Kaixin, Cheng Luqi, Wang Qi, He Yini, Guo Yitong, Xiao Fengqian, Tian Xiaohan, Xian Junxing, Zhang Changjiang, Wu Qian, Zou Yijuan, Li Long, Liu Bing, Wang Xiaoqun, Li Ang
Abstract excerpt
Despite advances in whole-brain imaging technologies, the lack of quantitative approaches to bridge rodent preclinical and human studies remains a critical challenge. Here we present TransBrain, a computational framework enabling bidirectional translation of brain-wide phenotypes between humans and mice. TransBrain improves human-mouse homology mapping accuracy through (1) a cortical and subcortical detached...
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