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Article

Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity.

Disease models & mechanisms - 1 Jan 2000

Hunter Jerrod W, Mullen Gregory P, McManus John R, Heatherly Jessica M, Duke Angie, Rand James B

Abstract excerpt

Neuroligins are postsynaptic cell adhesion proteins that bind specifically to presynaptic membrane proteins called neurexins. Mutations in human neuroligin genes are associated with autism spectrum disorders in some families. The nematode Caenorhabditis elegans has a single neuroligin gene (nlg-1), and approximately a sixth of C. elegans neurons, including some sensory neurons, interneurons and a subset of...

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Identifiers

PMID: 20083577
DOI: 10.1242/dmm.003442
PMCID: PMC4068633

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