Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

doi:10.1158/1055-9965.EPI-08-0168

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Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2008

Diergaarde Brenda, Potter John D, Jupe Eldon R, Manjeshwar Sharmila, Shimasaki Craig D, Pugh Thomas W, Defreese Daniele C, Gramling Bobby A, Evans Ilonka, White Emily

Abstract excerpt

Hormone therapy, estrogen plus progestin (E+P) particularly, is associated with increased risk of breast cancer. Functionally relevant polymorphisms in genes involved in sex hormone metabolism may alter exposure to exogenous sex hormones and affect risk of postmenopausal breast cancer. We evaluated associations of common polymorphisms in genes involved in estrogen and/or progesterone metabolism, E+P use, and...

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PMID: 18628428
DOI: 10.1158/1055-9965.EPI-08-0168
PMCID: PMC2732341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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