Article
IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin.
Cell death and differentiation - 1 Dec 2011
Liu B, Willette-Brown J, Liu S, Chen X, Fischer S M, Hu Y
Abstract excerpt
Inhibitor of nuclear factor κB kinase-α (IKKα) is required for maintaining skin homeostasis and preventing skin tumorigenesis. However, its signaling has not been extensively investigated. In the present study, we generated two mouse lines that expressed different levels of transgenic IKKα in the basal epidermis under the control of keratin-5 promoter and further evaluated their effects on the major pathways of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.