Article
IKKβ overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia.
Molecular cancer research : MCR - 1 Oct 2011
Page Angustias, Cascallana José L, Casanova M Llanos, Navarro Manuel, Alameda Josefa P, Pérez Paloma, Bravo Ana, Ramírez Angel
Abstract excerpt
Alterations in nuclear factor kappaB (NFκB) signaling have been related with several diseases and importantly also with cancer. Different animal models with increased or diminished NFκB signaling have shown that NFκB subunits and their regulators are relevant to the pathophysiology of different organs and tissues. In particular, both the deletion of the regulatory subunit β of the kinase of the inhibitor of NFκB...
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