Article
Diminished beta-adrenergic receptor responsiveness and cardiac dilation in hearts of myopathic Syrian hamsters (BIO 53.58) are associated with a functional abnormality of the G stimulatory protein.
Circulation - 1 Apr 1990
Feldman A M, Tena R G, Kessler P D, Weisman H F, Schulman S P, Blumenthal R S, Jackson D G, Van Dop C
Abstract excerpt
Previous studies have demonstrated a diminution in the bioactivity of the guanine nucleotide-binding regulatory protein that stimulates adenylyl cyclase (Gs) in hearts of the hypertrophic BIO 14.6 Syrian hamster. In this study, we measured functional activity and immunodetectable levels of Gs in...
Topics
- Adenylyl Cyclases
- Animals
- Cardiomyopathies
- Cricetinae
- GTP-Binding Proteins
- Heart
- Immunochemistry
- In Vitro Techniques
- Male
- Mesocricetus
- Mutation
- Myocardium
- Perfusion
- Receptors, Adrenergic, beta
- Tumor Cells, Cultured