Female-specific alterations in insulin dynamics are associated with glucose tolerance in a Glut1DS mouse model.

Abstract excerpt

Glucose transporter type 1 deficiency syndrome (Glut1DS) is a rare autosomal dominant genetic disorder caused by mutations in SLC2A1, which results in impaired glucose transport across the blood-brain barrier. Patients with Glut1DS present with various symptoms, including seizures, delayed development and movement disorders. The current first-line therapy - ketogenic diet - has shown variable efficacy,...

Topics

• Animals
• Female
• Insulin
• Disease Models, Animal
• Carbohydrate Metabolism, Inborn Errors
• Glucose Transporter Type 1