Article
The bacterial translocon SecYEG opens upon ribosome binding.
The Journal of biological chemistry - 21 Jun 2013
Knyazev Denis G, Lents Alexander, Krause Eberhard, Ollinger Nicole, Siligan Christine, Papinski Daniel, Winter Lukas, Horner Andreas, Pohl Peter
Abstract excerpt
In co-translational translocation, the ribosome funnel and the channel of the protein translocation complex SecYEG are aligned. For the nascent chain to enter the channel immediately after synthesis, a yet unidentified signal triggers displacement of the SecYEG sealing plug from the pore. Here, we show that ribosome binding to the resting SecYEG channel triggers this conformational transition. The purified and...
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