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Article

Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation.

The Journal of biological chemistry - 30 Jul 2010

Lycklama A Nijeholt Jelger A, Bulacu Monica, Marrink Siewert Jan, Driessen Arnold J M

Abstract excerpt

The SecYEG complex forms a protein-conducting channel in the inner membrane of Escherichia coli to support the translocation of secretory proteins in their unfolded state. The SecY channel is closed at the periplasmic face of the membrane by a small re-entrance loop that connects transmembrane segment 1 with 2b. This helical domain 2a is termed the plug domain. By the introduction of pairs of cysteines and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20489195
DOI: 10.1074/jbc.M110.124636
PMCID: PMC2911283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation.PMID 20489195Read ↗

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