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Article

RanBPM is essential for mouse spermatogenesis and oogenesis

12 May 2011

Abstract excerpt

RanBPM is a recently identified scaffold protein that links and modulates interactions between cell surface receptors and their intracellular signaling pathways. RanBPM has been shown to interact with a variety of functionally unrelated proteins; however, its function remains unclear. Here, we show that RanBPM is essential for normal gonad development as both male and female RanBPM(-/-) mice are sterile. In the...

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PMID: 21561988
DOI: 10.1242/dev.062505

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