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Article

Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization.

PloS one - 29 Apr 2011

Salehi-Had Hani, Roh Mi In, Giani Andrea, Hisatomi Toshio, Nakao Shintaro, Kim Ivana K, Gragoudas Evangelos S, Vavvas Demetrios, Guccione Samira, Miller Joan W

Abstract excerpt

PURPOSE: The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. METHODS: CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and gene delivery was...

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Identifiers

PMID: 21559527
DOI: 10.1371/journal.pone.0018864
PMCID: PMC3084713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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