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Article

AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression

13 Aug 2019

Abstract excerpt

There has been great progress in ocular gene therapy, but delivery of viral vectors to the retinal pigmented epithelium (RPE) and retina can be challenging. Subretinal injection, the preferred route of delivery for most applications, requires a surgical procedure that has risks. Herein we report a novel gene therapy delivery approach, suprachoroidal injection of AAV8 vectors, which is less invasive and could be...

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PMID: 31408444
DOI: 10.1172/jci129085

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