Article
Tumor regression by targeted gene delivery to the neovasculature.
Science (New York, N.Y.) - 28 Jun 2002
Hood John D, Bednarski Mark, Frausto Ricardo, Guccione Samira, Reisfeld Ralph A, Xiang Rong, Cheresh David A
Abstract excerpt
Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of targeting vectors specific for endothelial cells in diseased tissues. Here we show that a cationic nanoparticle (NP) coupled to an integrin alphavbeta3-targeting ligand can deliver genes selectively to angiogenic blood vessels in tumor-bearing mice. The therapeutic efficacy of this approach was tested by generating...
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