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Intraocular RGD-Engineered Exosomes and Active Targeting of Choroidal Neovascularization (CNV)

18 Aug 2022

Abstract excerpt

Purpose: To assess the transretinal penetration of intravitreally injected retinal multicell-derived exosomes and to develop exosome-based active targeting of choroidal neovascularization (CNV) by bioengineering with ASL, which is composed of a membrane Anchor (BODIPY), Spacer (PEG), and targeting Ligands (cyclic RGD peptide). Methods: Retinal multicell-derived exosomes were recovered from a whole mouse retina...

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PMID: 36010651
DOI: 10.3390/cells11162573

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