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Article

In vivo optical imaging of integrin αV-β3 in mice using multivalent or monovalent cRGD targeting vectors

12 Jun 2007

Abstract excerpt

BACKGROUND: The cRGD peptide is a promising probe for early non-invasive detection of tumors. This study aimed to demonstrate how RAFT-c(-RGDfK-)4, a molecule allowing a tetrameric presentation of cRGD, improved cRGD-targeting potential using in vivo models of alphaVbeta3-positive or negative tumors. RESULTS: We chose the human embryonic kidney cells HEK293(beta3) (high levels of alphaVbeta3) or HEK293(beta1)...

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PMID: 17565663
DOI: 10.1186/1476-4598-6-41

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