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Article

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.

Oncotarget - 15 Nov 2014

Yan Ying, Hein Ashley L, Etekpo Asserewou, Burchett Katrina M, Lin Chi, Enke Charles A, Batra Surinder K, Cowan Kenneth H, Ouellette Michel M

Abstract excerpt

Radiation therapy is a staple treatment for pancreatic cancer. However, owing to the intrinsic radioresistance of pancreatic cancer cells, radiation therapy often fails to increase survival of pancreatic cancer patients. Radiation impedes cancer cells by inducing DNA damage, which can activate ce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25344910
DOI: 10.18632/oncotarget.2500
PMCID: PMC4279370

Genes

RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25344910-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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