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Article

SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2018

Wang Feng, Xia Xiaojun, Yang Chunying, Shen Jianliang, Mai Junhua, Kim Han-Cheon, Kirui Dickson, Kang Ya'an, Fleming Jason B, Koay Eugene J, Mitra Sankar, Ferrari Mauro, Shen Haifa

Abstract excerpt

Purpose: Understanding the mechanism of radioresistance could help develop strategies to improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently mutated in pancreatic cancer. In this study, we investigated the role of SMAD4 deficiency in pancreatic cancer cells' response to radiotherapy.Experimental Design: We downregulated SMAD4 expression with SMAD4 siRNA or SMAD4 shRNA and...

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Identifiers

PMID: 29602802
DOI: 10.1158/1078-0432.CCR-17-3435
PMCID: PMC6345154

Genes

SMAD4

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