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Article

Contextual regulation of pancreatic cancer stem cell phenotype and radioresistance by pancreatic stellate cells.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 May 2014

Al-Assar Osama, Demiciorglu Fevzi, Lunardi Serena, Gaspar-Carvalho Maria Manuela, McKenna William Gillies, Muschel Ruth M, Brunner Thomas B

Abstract excerpt

BACKGROUND AND PURPOSE: Progression of pancreatic ductal adenocarcinoma (PDAC) is promoted by desmoplasia induced by pancreatic stellate cells (PSC). Contributory to this progression is epithelial mesenchymal transition (EMT), which shares many characteristics with the cancer stem cell (CSC) hypothesis. We investigated the role of these processes on the radioresponse and tumorigenicity of pancreatic cancer cells....

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Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial-Mesenchymal Transition

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Source

Identifiers

PMID: 24780634
DOI: 10.1016/j.radonc.2014.03.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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