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Article

Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis.

European journal of immunology - 1 Aug 2011

Pizon Mathieu, Rampanarivo Hariniaina, Tauzin Sébastien, Chaigne-Delalande Benjamin, Daburon Sophie, Castroviejo Michel, Moreau Patrick, Moreau Jean-François, Legembre Patrick

Abstract excerpt

The immune system eliminates infected or transformed cells through the activation of the death receptor CD95. CD95 engagement drives the recruitment of the adaptor protein Fas-associated death domain protein (FADD), which in turn aggregates and activates initiator caspases-8 and -10. The CD95-mediated apoptotic signal relies on the capacity to form the CD95/FADD/caspases complex termed the death-inducing...

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PMID: 21557211
DOI: 10.1002/eji.201041078

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FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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