Article
Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians.
Cardiology - 1 Jan 2011
Jabbari Javad, Olesen Morten S, Holst Anders G, Nielsen Jonas B, Haunso Stig, Svendsen Jesper H
Abstract excerpt
OBJECTIVES: The aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels. Furthermore, we wanted to replicate the prior association of two single-nucleotide polymorphisms (SNPs) in KCNJ5, C171T (rs6590357) and G810T (rs7118824), with lone AF in Han Chinese. METHODS: We sequenced the coding region and splice site of...
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