Article
The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population.
Cardiology - 1 Jan 2007
Zeng Zhiyu, Tan Chen, Teng Siyong, Chen Jianhong, Su Shaoyong, Zhou Xiaoyang, Wang Fangzheng, Zhang Shu, Gu Dongfeng, Makielski Jonathan C, Pu Jielin
Abstract excerpt
Recent studies suggest that genetic mutation of the slow delayed rectifier potassium channel (I(Ks)) may underlie atrial fibrillation (AF). We investigated the association between AF and the single nucleotide polymorphisms (SNPs) of genes KCNQ1, KCNE1 and KCNE4 associated with this channel. Common non-synonymous SNPs in KCNQ1 and KCNE1 known to be frequent in Asian people were selected and direct sequencing of...
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