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Article

Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2016

Katsuoka Fumiki, Yamazaki Hiromi, Yamamoto Masayuki

Abstract excerpt

Nrf1 and Nrf2 (NF-E2-related factors 1 and 2, respectively) are transcription factors that belong to the Cap'n'collar (CNC) family and play critical roles in various tissues, including the liver. Liver-specific Nrf1 knockout mice show hepatic steatosis, accompanied by dysregulation of various metabolic genes. Nrf2 knockout mice show impairment in the induction of antioxidant and xenobiotic-metabolizing enzyme...

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PMID: 27723178
DOI: 10.1111/gtc.12445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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