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Article

Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.

Molecular and cellular biology - 1 Apr 2004

Derjuga Anna, Gourley Tania S, Holm Teresa M, Heng Henry H Q, Shivdasani Ramesh A, Ahmed Rafi, Andrews Nancy C, Blank Volker

Abstract excerpt

Cap'n'collar (CNC) family basic leucine zipper transcription factors play crucial roles in the regulation of mammalian gene expression and development. To determine the in vivo function of the CNC protein Nrf3 (NF-E2-related factor 3), we generated mice deficient in this transcription factor. We performed targeted disruption of two Nrf3 exons coding for CNC homology, basic DNA-binding, and leucine zipper...

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Source

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Identifiers

PMID: 15060151
DOI: 10.1128/MCB.24.8.3286-3294.2004
PMCID: PMC381672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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