Article
Mammosphere cells from high-passage MCF7 cell line show variable loss of tumorigenicity and radioresistance.
Cancer letters - 1 Mar 2012
Xie Guozhu, Zhan Junfang, Tian Yunhong, Liu Ying, Chen Zhixian, Ren Chen, Sun Quanquan, Lian Jianping, Chen Longhua, Ruan Jian, Ye Changsheng, Sun Aimin, Yuan Yawei
Abstract excerpt
Mammosphere culture of cancer cell lines is an important approach used for enrichment of stem-like cancer cells (SLCs), but over-subcultured cell lines have been experimentally shown to change properties over time. It remains unclear if mammosphere cells (MSs) derived from high-passage cancer cell lines retain the tumorigenicity and radioresistance seen in MSs from primary or low-passage cell lines. In this...
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