Article
Genome partitioning of genetic variation for complex traits using common SNPs.
Nature genetics - 1 Jun 2011
Yang Jian, Manolio Teri A, Pasquale Louis R, Boerwinkle Eric, Caporaso Neil, Cunningham Julie M, de Andrade Mariza, Feenstra Bjarke, Feingold Eleanor, Hayes M Geoffrey, Hill William G, Landi Maria Teresa, Alonso Alvaro, Lettre Guillaume, Lin Peng, Ling Hua, Lowe William, Mathias Rasika A, Melbye Mads, Pugh Elizabeth, Cornelis Marilyn C, Weir Bruce S, Goddard Michael E, Visscher Peter M
Abstract excerpt
We estimate and partition genetic variation for height, body mass index (BMI), von Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated individuals. We estimate that ∼45%, ∼17%, ∼25% and ∼21% of the variance in height, BMI, von Willebrand factor and QTi, respectively, can be explained by all autosomal SNPs and a further ∼0.5-1% can be explained by X chromosome SNPs. We show...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.