Article
Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2011
Panchanathan Ravichandran, Shen Hui, Duan Xin, Rathinam Vijay A K, Erickson Loren D, Fitzgerald Katherine A, Choubey Divaker
Abstract excerpt
Murine Aim2 and Ifi202 genes (encoding for the Aim2 and p202 proteins) are members of the IFN-inducible Ifi200 gene family. The Aim2 deficiency in mice activates IFN signaling and stimulates the expression of the lupus susceptibility gene, the Ifi202, located within the NZB autoimmunity 2 (Nba2) interval. Given that the deficiency in the expression of the Fcgr2b gene (encoding for the inhibitory FcγRIIB receptor)...
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