Article
Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs.
The Journal of biological chemistry - 1 Jul 2011
Zhou Xixi, Sun Xi, Cooper Karen L, Wang Feng, Liu Ke Jian, Hudson Laurie G
Abstract excerpt
Arsenic inhibits DNA repair and enhances the genotoxicity of DNA-damaging agents such as benzo[a]pyrene and ultraviolet radiation. Arsenic interaction with DNA repair proteins containing functional zinc finger motifs is one proposed mechanism to account for these observations. Here, we report that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose)...
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