Article
Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc.
Toxicology and applied pharmacology - 1 Jun 2013
Cooper Karen L, King Brenee S, Sandoval Monica M, Liu Ke Jian, Hudson Laurie G
Abstract excerpt
Arsenic is a recognized human carcinogen and there is evidence that arsenic augments the carcinogenicity of DNA damaging agents such as ultraviolet radiation (UVR) thereby acting as a co-carcinogen. Inhibition of DNA repair is one proposed mechanism to account for the co-carcinogenic actions of arsenic. We and others find that arsenite interferes with the function of certain zinc finger DNA repair proteins....
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