Article
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
The Journal of biological chemistry - 17 Nov 2000
Kapahi P, Takahashi T, Natoli G, Adams S R, Chen Y, Tsien R Y, Karin M
Abstract excerpt
Arsenite is a potent environmental toxin that causes various pathologies including cancers and skin disorders. Arsenite is believed to exert its biological effects through reaction with exposed sulfhydryl groups, especially pairs of adjacent thiols. Here, we describe the mechanism by which arsenite affects the NF-kappaB signaling pathway. Activation of transcription factor NF-kappaB depends on the integrity of...
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