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Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent

3 Apr 2019

Abstract excerpt

Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and arsenic trioxide, that have a Pt(II) bond to an As(III) hydroxide center. Screens of the NCI-60 human tumor cell lines reveal that arsenoplatin-1 (AP-1), [Pt(μ-NHC(CH 3 )O) 2 ClAs(OH) 2 ], the first representative of this novel class of anticancer agents, displays a superior activity profile relative to the parent drugs As 2 O 3...

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PMID: 30943017
DOI: 10.1021/jacs.8b13681

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