Article
Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter.
Xenotransplantation - 1 Nov 2006
Godwin James W, Fisicaro Nella, d'Apice Anthony J F, Cowan Peter J
Abstract excerpt
BACKGROUND: Targeting protective gene expression to porcine endothelium has obvious advantages in xenotransplantation, but no endothelial cell-specific promoters have yet been used successfully in transgenic pigs. We have previously reported that a human intercellular adhesion molecule-2 (ICAM-2) gene promoter fragment functioned efficiently in transgenic mice but not pigs, suggesting that it lacked important...
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